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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Dehydrobruceine B, Cisplatin
Phytochemical Name Dehydrobruceine B (PubChem CID: 101967133 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 584
Ref_1
Pair Name Dehydrobruceine B, Cisplatin
Disease Info [ICD-11: 2C25.Z] Lung cancer Investigative
Biological Phenomena Induction-->Mitochondria-mediated apoptosis
Gene Regulation Up-regulation Expression CYCS hsa54205
Up-regulation Cleavage AIFM1 hsa9131
Down-regulation Expression BCL2 hsa596
Up-regulation Expression BAX hsa581
Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP9 hsa842
Up-regulation Cleavage PARP1 hsa142
Down-regulation Expression NFE2L2 hsa4780
Down-regulation Expression NQO1 hsa1728
Down-regulation Expression ABCC1 hsa4363
Down-regulation Expression ABCC2 hsa1244
Down-regulation Expression GCLC hsa2729
In Vitro Model A-549 Lung adenocarcinoma Homo sapiens (Human) CVCL_0023
Result These results generated a rationale for further investigation of DHB combined with CDDP as a potential therapeutic strategy in lung cancer.
03. Reference
No. Title Href
1 Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells. Biomed Pharmacother. 2017 May;89:623-631. doi: 10.1016/j.biopha.2017.02.055. Click
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